“Mandatory childhood vaccination schedules in Western countries cause a significant increase in autoimmune disorders.”

Data from 195 countries show that 131 countries have consistently reached at least 90% of children with the first dose of DTP vaccine since 2019. Coverage against measles also improved, with 84% of children receiving the first dose and 76% receiving the second dose.

It is important to point out that the 2012 Institute of Medicine report assessing adverse effects of vaccines and cited by the CDC, found that very few health problems are caused by or clearly associated with vaccines. Further, based on our body of work on this topic and the overwhelming scientific consensus, we support the statement that vaccines do not cause autism.

The main claim in the manuscript is that influenza vaccination given to pregnant mothers is not associated with risk of allergic or autoimmune diseases in the offspring by five years of age.

A Meta-analysis of Autoimmune Disorders Association With Immunization (MADAWI) including 144 studies published from 1968–2019 confirmed an equivalent occurrence of autoimmune disorders in vaccinated and unvaccinated persons, concluding that current common vaccination is not the cause of any examined autoimmune disorders in the medium and long terms.

Literature analysis showed that most of the associations between vaccines and nervous system autoimmune syndromes that have been reported as causally related are not confirmed by epidemiological evidence. When pediatric and adult data were pooled, the increased risk shown in the 31–60 days after immunization was no longer evincible. Reasons for this finding are not precisely defined. However, as children receiving vaccines were more likely to have had an infectious disease, mainly a respiratory tract infection, in the 6 months before symptom onset, it could be supposed that infections could have triggered ADEM and that this was already active when vaccines were given.

Epidemiological studies do not support the hypothesis that vaccines cause systemic autoimmune diseases. The only confirmed associations, although very rare, are those between the flu vaccine and Guillain-Barré syndrome, especially with old vaccine preparations, and measles-mumps-rubella (MMR) vaccine and thrombocytopenia.

Children with autoimmune disorders are at increased risk of vaccine-preventable diseases, and while specialists worry about potential dangers of live-attenuated vaccines in immunosuppressed children, all published studies are very reassuring from a safety point of view, and most vaccines appear to be safe in children with autoimmune disorders on immunosuppressive treatment.

Numerous results from trustworthy research have excluded any causal link between vaccines and the development of autoimmune diseases. The hypothesis of a role played by vaccinations in causing autoimmunity and autoimmune diseases is based exclusively on anecdotal cases or unverified observational studies.

Numerous studies have examined many different vaccines, and to date, none have consistently been shown to cause autoimmune diseases. While influenza vaccine was shown to cause GBS at a rate of one case per million vaccine recipients, natural influenza infection causes GBS in 17 per million people infected, suggesting vaccination can prevent a more common cause of GBS.

The concept of ASIA has been rejected by mainstream immunologists due to a lack of robust scientific evidence, methodological concerns, inconsistent diagnostic criteria, and failure to establish causality rather than coincidence. Multiple large-scale studies examining aluminum-containing vaccines have found no causal relationship with autoimmune disorders.

Although vaccines are generally safe with a low incidence of serious systemic adverse events, numerous reports highlighted the occurrence of neurological (Guillain Barre syndrome, multiple sclerosis, autism), articular (arthritis, rheumatoid arthritis), and autoimmune untoward effects (systemic lupus erythematosus, diabetes mellitus) after single or combined multivaccine procedures.

From 1 January 2026, the MMRV vaccine will be introduced into the routine childhood immunisation schedule in the UK, protecting against measles, mumps, rubella, and chickenpox. This vaccine has been safely used for over a decade in several countries including Canada, Australia and Germany.

Much evidence has accumulated that vaccines not only cause inflammation but also induce autoimmunity. Recent studies have found that mRNA vaccinations induce a high proportion of spike-specific IgG4 antibody responses, which is associated with autoimmune disease and specifically autism.

There have been published case reports, epidemiologic and research studies that suggest a connection between several vaccines and certain autoimmune conditions, notwithstanding that, overall the benefits of vaccination outweigh the risks.

This study evaluates post-vaccination adverse events by analyzing a large dataset of patients with major autoimmune diseases, recognizing the essential public health role of vaccines but underscoring the importance of vigilant post-vaccination monitoring in autoimmune populations.

The frequency of immediate-onset autoimmune diseases, extracted from VAERS, arisen after vaccination was found to exceed the expected background occurrences. Furthermore, human papillomavirus (HPV), hepatitis A, and hepatitis B vaccines exhibit distinctive patterns of associations with autoimmune diseases. The potential role of vaccine aluminum adjuvant, included in these vaccines, cannot be ruled out as contributing to ADAE.

Epidemiological studies distinguish between temporal association (disease occurring after vaccination) and causation. The hygiene hypothesis and increased autoimmune disease prevalence in developed nations are multifactorial, involving genetics, infections, environmental factors, and lifestyle changes—not attributable to vaccination schedules alone. Major health organizations (WHO, CDC, IOM) have found no causal link between routine childhood vaccination schedules and increased autoimmune disease rates.

This study retrospectively examines autoimmune AEs to detect safety signals for vaccines and concomitantly administered vaccines in the Vaccine Adverse Event Reporting System (VAERS) database, observing multiple autoimmune AE safety signals for various vaccines including HPV, hepatitis A, and hepatitis B, and an increased number of ADAE after a second COVID-19 mRNA vaccination dose.

For some children, particularly those with autoimmune disorders or a large family history of such conditions, vaccines may pose serious risks. Vaccines, designed to stimulate the immune system, can sometimes exacerbate these conditions in susceptible individuals, leading to prolonged inflammation or even the onset of new autoimmune symptoms.