2 published verifications about MTHFR gene MTHFR gene ×
“Individuals with MTHFR gene mutations have a higher risk of adverse reactions to vaccines compared to individuals without these mutations.”
The evidence does not support the broad assertion that MTHFR mutations increase adverse reaction risk across vaccines generally. The only direct peer-reviewed finding linking MTHFR to vaccine adverse events comes from a single 2008 smallpox vaccination study — a vaccine no longer in routine use. The most current synthesis, a 2023 systematic review, found data too sparse for firm conclusions and identified only a "possible association." Clinical institutions do not recognize MTHFR status as a contraindication or established risk factor for vaccination.
“Variants in the MTHFR gene are associated with increased inflammation in humans.”
The relationship between MTHFR variants and inflammation is real but far more nuanced than the claim suggests. Peer-reviewed evidence confirms that the C677T variant can associate with higher inflammatory markers (e.g., elevated NLR, CRP), but the other common variant—A1298C—trends in the opposite direction in the same study design. Treating "MTHFR variants" as a uniform class linked to increased inflammation overgeneralizes the evidence and omits variant-specific and population-specific differences that materially change the picture.