2 verifications about Aromatase Aromatase ×
“Low muscle mass causes excessive aromatase activity.”
The cited evidence does not establish low muscle mass as a cause of excessive aromatase activity. Higher aromatase activity and reduced lean mass can occur together, but the available research primarily identifies adiposity and expanded adipose tissue as the relevant drivers. Evidence that muscle expresses aromatase—or that aromatase can affect muscle—does not support the claimed causal direction.
“Smoking in women can cause aromatase deficiency.”
The evidence does not support the claim as stated. Smoking and nicotine can inhibit aromatase activity and lower estrogen in women, but that is not the same as causing aromatase deficiency, which is a rare genetic disorder caused by CYP19A1 mutations. The claim conflates temporary enzyme inhibition with a distinct inherited medical condition.