2 verifications about Enterocytes Enterocytes ×
“Reduced perfusion of the small-intestinal mucosa can impair enterocyte renewal and contribute to villous blunting (villous atrophy), reducing absorptive surface area.”
Evidence supports this mechanism. Reduced small-intestinal mucosal perfusion can impair epithelial renewal, promote enterocyte loss, and contribute to villous blunting, which lowers absorptive surface area. The strongest data come from ischemia, shock, and sustained hypoperfusion models, but the claim is appropriately cautious in saying this can occur and can contribute.
“Physiologic stress can increase intestinal permeability by disrupting tight junctions between enterocytes, which increases translocation of luminal antigens and bacteria.”
The literature strongly supports that stress can impair the intestinal barrier by altering tight-junction function and increasing permeability. Reviews, animal studies, and cell studies also link this barrier disruption to greater passage of luminal antigens and, in some models, bacteria. The main caveat is that the full causal chain is demonstrated most directly in animal and in vitro research; human evidence is stronger for permeability changes than for direct bacterial translocation.