2 verifications about Neurotransmitters Neurotransmitters ×
“The human gut microbiome produces enough neurotransmitters to directly influence human personality traits and temperament.”
The evidence does not support a direct microbiome-to-personality effect through microbial neurotransmitters. Gut microbes do make neuroactive chemicals, but these generally do not cross into the brain in amounts that would directly shape personality or temperament. Current human research mainly suggests indirect gut-brain signaling and possible links to mood or symptoms, not proven direct control of stable personality traits.
“Creatine supplementation reduces demand for S-adenosylmethionine (SAMe), thereby increasing SAMe availability for neurotransmitter production.”
Creatine likely reduces the body’s need to synthesize as much creatine, lowering one major use of SAMe-derived methyl groups. But the evidence does not show that this spared capacity is actually redirected into neurotransmitter production. Human studies on methylation proxies are mixed, and reviews of creatine’s brain effects describe the neurotransmitter pathway as indirect or unproven.